(PUD; Duodenal Ulcer; Ulcer, Peptic; Ulcer, Duodenal)
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- Helicobacter pylori ( H. pylori ) infection
- Use of nonsteroidal anti-inflammatory drugs (NSAIDs)
- H. pylori infection
- Taking NSAIDs for a long time and at higher doses
- Prior peptic ulcer disease
- Cigarette smoking
- Alcohol use disorder
- May awaken you from sleep
- May change when you eat
- May last for a few minutes or several hours
- Feels like unusually strong hunger pangs
- May be relieved by taking antacids
- Loss of appetite
- Weight loss
- Bloody or black, tarry stools
- Vomiting what looks like coffee grounds or blood
- Antibiotics if an infection is present or possible
- Over-the-counter antacids
- Proton pump inhibitors
- H-2 blockers
- Medications to coat ulcer
- Medications to protect stomach against NSAID damage
- Quit smoking . Smoking worsens symptoms and slows healing.
- Limit alcohol intake.
- Avoid NSAIDs. This includes common over-the-counter drugs like aspirin and ibuprofen .
Surgery and Endoscopy
- An ulcer that won't heal
- Recurring ulcers
- A bleeding ulcer
- A perforated ulcer
- Problems with food passing out of stomach
- Removal of the ulcer
- Removal of part of the stomach or small intestine
- Tying off the bleeding blood vessel
- Taking tissue from another part of the intestine and oversewing the ulcer
- Cutting part of the nerve that goes to the stomach to reduce acid production
- Wash your hands after using the bathroom and before eating or preparing food.
- Drink water from a safe source.
- Don't smoke . Cigarette smoking increases the chances of getting an ulcer.
- Use other drugs when possible for managing pain.
- Take the lowest possible dose.
- Don't take drugs longer than needed.
- Don't drink alcohol while taking the drugs.
- Ask your doctor about switching to medicines less likely to cause ulcers. Talk to your doctor about taking other drugs to protect your stomach and intestine lining.
- Don't smoke. Cigarette smoking increases the chances of getting an ulcer.
Gastro—American Gastroenterological Association http://www.gastro.org
The American College of Gastroenterology http://patients.gi.org
Canadian Association of Gastroenterology http://cag-acg.org
Health Canada http://www.hc-sc.gc.ca
Meurer LN, Bower DJ. Management of helicobacter pylori infection. Am Fam Physician. 2002;65(7):1327-1336.
Peptic ulcer disease. American College of Gastroenterology website. Available at: http://patients.gi.org/topics/peptic-ulcer-disease. Accessed April 29, 2013.
Peptic ulcer disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated April 22, 2013. Accessed April 29, 2013.
Peptic ulcers and H. pylori. National Digestive Diseases Information Clearinghouse website. Available at: http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/peptic-ulcer/Documents/hpylori%5F508.pdf. Updated April 30, 2012. Accessed April 29, 2013.
Understanding peptic ulcer disease. American Gastroenterological Association website. Available at: http://www.gastro.org/patient-center/digestive-conditions/peptic-ulcer-disease. Accessed April 29, 2013.
- Reviewer: Daus Mahnke, MD
- Review Date: 02/2015 -
- Update Date: 05/07/2014 -